Donna Dierker, MSᵃ, Jarod L. Roland, MDᵇ, Mudassar Kamran, MDᵃ, Jerrel Rutlin, BAᵃ, Carl D. Hacker, MD, PhDᵈ, Daniel S. Marcus, PhDᵃ, Mikhail Milchenko, PhDᵃ, Michelle M. Miller-Thomas, MDᵃ, Tammie L. Benzinger, MD, PhDᵃᵇ, Abraham Z. Snyder, MD, PhDᵃᶜ, Eric C. Leuthardt, MDᵃᵈ,* and Joshua S. Shimony, MD, PhDᵃ,*

ᵃMallinckrodt Institute of Radiology

ᵇDepartment of Neurological Surgery

ᶜDepartment of Neurology

ᵈDepartment of Biomedical Engineering

Synopsis

The goal of this article is to compare resting state fMRI with task fMRI as a tool for presurgical functional mapping of the sensorimotor (SM) region. Prior to tumor resection, 38 patients were scanned using both methods. The SM area was anatomically defined using two different software tools. Overlap of anatomical regions of interest with task activation maps and resting state networks was measured in the SM region. A paired t-test showed higher overlap between resting state maps and anatomical references as compared to task activation when using a maximal overlap criterion. Resting state derived maps are more comprehensive than those derived from task fMRI.